Monday, March 1, 2021
Home Health Researchers test new combination therapy for head and neck cancer | Health...

Researchers test new combination therapy for head and neck cancer | Health News


Washington: Researchers at the University of Cincinnati have tested a new combination therapy in animal models to see if they could find a way to make an already effective treatment even better. Since they`re using a Food and Drug Administration-approved drug to do it, this could help humans sooner than later.

These findings are published in the journal Cancer Letters. Christina Wicker, PhD, a postdoctoral fellow in the lab of Vinita Takiar, MD, PhD, led this research which she says will hopefully extend the lives of patients one day.”Head and neck cancer, like any cancer, is truly life-altering,” she says.

“Head and neck cancer could impact your throat, tongue or nose, and patients often can`t swallow, talk or eat; it truly takes away some of the most social, enjoyable parts of life.”

Researchers in this study combined radiation therapy with a drug (telaglenastat) that stops a key enzyme in a cell pathway that becomes altered in cancer cells, causing those cells to grow rapidly and resist treatment. Wicker says this drug has already been studied in multiple clinical trials to see if it could improve treatment of various cancers.

“Until now, no one has examined if this drug has the potential to improve radiation treatment in head and neck cancer. Most importantly, this drug compound has been well tolerated by patients and causes minimal side effects,” she says.

Using animal models, researchers found that the drug alone reduced the growth of head and neck cancer cells up to 90 per cent, and it also increased the efficacy of radiation in animals with head and neck tumours by 40 per cent. “With these results, and especially with previous clinical trials showing that the drug is well tolerated by patients, there is the potential to move more rapidly into head and neck cancer clinical trials,” Wicker says.

“In the future, we hope this drug will be used to make radiation treatments for head and neck cancer even more effective.” Currently, the most common treatment for that cancer is radiation therapy, but cancer eventually returns in up to half of the patients, Wicker says, and often it doesn`t respond as positively to treatment the second time around.”When [traditional] drugs are less effective, cancer growth becomes difficult to control, which can lead to the cancer quickly spreading to other organs,” she says.”It is very important that scientists and clinicians develop new cancer treatments to improve treatment of this type of cancer, and hopefully our findings will provide one more option to help patients.”

(function(d, s, id) {
var js, fjs = d.getElementsByTagName(s)[0];
if (d.getElementById(id)) return;
js = d.createElement(s); js.id = id;
js.src = “https://connect.facebook.net/en_US/sdk.js#xfbml=1&version=v2.9”;
fjs.parentNode.insertBefore(js, fjs);
}(document, ‘script’, ‘facebook-jssdk’));

(function ($) {
/*Drupal.behaviors.pagerload = {
attach: function (context, settings) {*/
$(document).ready(function(){
$(“.sidebar”).theiaStickySidebar();
/*$.get( “/hindi/zmapp/mobileapi/sections.php?sectionid=17,18,19,23,21,22,25,20”, function( data ) {
$( “#sub-menu” ).html( data );
alert( “Load was performed.” );
});*/
var nextpath=””; var pg = 1;
var nextload= true;
var string = ”;var ice = 0;
var playerFly;
var load = ‘

Loading

‘;
var cat = “?cat=120172”;
//$(“.main-rhs2337506″).theiaStickySidebar();
var instagram_script=document.createElement(‘script’);
instagram_script.defer=”defer”;
instagram_script.async=”async”;
instagram_script.src=”https://platform.instagram.com/en_US/embeds.js”;
document.head.appendChild(instagram_script);
/*************************************/
/*$(window).scroll(function(){
var last = $(‘div.listing’).filter(‘div:last’);
var lastHeight = last.offset().top ;
if(lastHeight + last.height() = 360) {
angle = 1;
}
angle += angle_increment;
}.bind(this),interval);
},
success: function(data){
nextload=false;
//console.log(“success”);
//console.log(data);
$.each(data[‘rows’], function(key,val){
//console.log(“data found”);
ice = 2;
if(val[‘id’]!=’2337506′){
string = ‘

‘ + val[“title”] + ‘

‘ + val[“summary”] + ‘

‘;
$(‘div.listing’).append(string);
}
});
},
error:function(xhr){
//console.log(“Error”);
//console.log(“An error occured: ” + xhr.status + ” ” + xhr.statusText);
nextload=false;
},
complete: function(){
$(‘div.listing’).find(“.loading-block”).remove();;
pg +=1;
//console.log(“mod” + ice%2);
nextpath=”&page=” + pg;
//console.log(“request complete” + nextpath);
cat = “?cat=120172”;
//console.log(nextpath);
nextload=(ice%2==0)?true:false;
}
});

}
//lastoff = last.offset();
//console.log(“**” + lastoff + “**”);
});*/
var maindiv = false;
var dis = 0;
var fbcontainer=””;
var fbid = ”;
var fb_script=document.createElement(‘script’);
fb_script.text= “(function(d, s, id) {var js, fjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) return;js = d.createElement(s); js.id = id;js.src=”https://connect.facebook.net/en_GB/sdk.js#xfbml=1&version=v2.9″;fjs.parentNode.insertBefore(js, fjs);}(document, ‘script’, ‘facebook-jssdk’));”;
var fmain = $(“.sr2337506”);
//alert(x+ “-” + url);
var fdiv = ‘

‘;
//console.log(fdiv);
//$(fb_script).appendTo(fmain);
$(fdiv).appendTo(fmain);
function fillElementWithAd($el, slotCode, size, targeting){
if (typeof targeting === ‘undefined’) {
targeting = {};
} else if ( Object.prototype.toString.call( targeting ) !== ‘[object Object]’ ) {
targeting = {};
}
var elId = $el.attr(‘id’);
//console.log(“elId:” + elId);
googletag.cmd.push(function(){
var slot = googletag.defineSlot(slotCode, size, elId);
for (var t in targeting){
slot.setTargeting(t, targeting[t]);
}
slot.addService(googletag.pubads());
googletag.display(elId);
//googletag.pubads().refresh([slot]);
});
}
$(document).delegate(“button[id^=’mf’]”, “click”, function(){
fbcontainer=””;
fbid = ‘#’ + $(this).attr(‘id’);
var sr = fbid.replace(“#mf”, “.sr”);
$(fbid).parent().children(sr).toggle();
fbcontainer = $(fbid).parent().children(sr).children(“.fb-comments”).attr(“id”);
});

function onPlayerStateChange(event){
var ing, fid;
//console.log(event + “—player”);
$(‘iframe[id*=”video-“]’).each(function(){
_v = $(this).attr(‘id’);
//console.log(“_v: ” + _v);
if(_v != event){
//console.log(“condition match”);
ing = new YT.get(_v);
if(ing.getPlayerState()==’1′){
ing.pauseVideo();
}
}
});
$(‘div[id*=”video-“]’).each(function(){
_v = $(this).attr(‘id’);
//console.log(“_v: ” + _v + ” event: ” + event);
if(_v != event){
//jwplayer(_v).play(false);
}
});
}
function onYouTubePlay(vid, code, playDiv,vx, pvid){
if (typeof(YT) == ‘undefined’ || typeof(YT.Player) == ‘undefined’) {
var tag = document.createElement(‘script’);
tag.src = “https://www.youtube.com/iframe_api”;
var firstScriptTag = document.getElementsByTagName(‘script’)[0];
firstScriptTag.parentNode.insertBefore(tag, firstScriptTag);
window.onYouTubePlayerAPIReady = function() {
onYouTubePlayer(vid, code, playDiv,vx, pvid);
};
}else{onYouTubePlayer(vid, code, playDiv,vx, pvid);}
}
function onYouTubePlayer(vid, code, playDiv,vx, pvid){
//console.log(playDiv + “Get Youtue ” + vid);
//$(“#”+vid).find(“.playvideo-“+ vx).hide();
var player = new YT.Player(playDiv , {
height: ‘450’,
width: ‘100%’,
videoId:code,
playerVars: {
‘autoplay’: 1,
‘showinfo’: 1,
‘controls’: 1
},
events: {
‘onStateChange’: function(event){
onPlayerStateChange(event.target.a.id);
}
}
});
$(“#video-“+vid).show();
}
function kalturaPlayerAPIReady(code, playDiv,pvid){
var dt=new Date;
var nt=dt.getTime();
var vtitle = “”;
pre_roll = “https://pubads.g.doubleclick.net/gampad/ads?sz=640×480&iu=/11440465/Zeenews_English_Video/Zeenews_English_Preroll&tfcd=0&npa=0&sz=640×480&gdfp_req=1&output=vast&unviewed_position_start=1&env=vp&impl=s&description_url=”+vtitle+”&correlator=”+nt;

var sources ={};
var config = {
targetId: playDiv,
provider: {
partnerId: 2504201
},
playback: {
pictureInPicture : true,
autoplay: true
},
advertising: {
adBreaks: [{
position: 0,
ads: [{
url: [pre_roll]
}]
}]
},
plugins: {
ima: {
adsResponse: “”
}
}
}
var kalturaPlayer = KalturaPlayer.setup(config);
if(kalturaPlayer){
kalturaPlayer.reset();
}
var videoUrl = code;
var mediaid = ‘”zn’ + pvid + ‘”‘;
sources = {
hls: [{
id: mediaid,
url: videoUrl,
mimetype: “application/x-mpegURL”
}]
}
kalturaplayerSetup(kalturaPlayer, sources);
if (typeof kalturaPlayer !== ‘undefined’) {
doRegisterEvents(kalturaPlayer);
}
}
function kalturaplayerSetup(kalturaPlayer, playbackType){
kalturaPlayer.setMedia({
plugins: {},
sources: playbackType
});
}

function doRegisterEvents(kalturaPlayer) {
/* player event*/
kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PLAY, playEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PAUSE, pauseEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.Core.PLAYBACK_ENDED, playbackEndedEvent);

/* ad event */
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_STARTED, adStartedEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_COMPLETED, adCompletedEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_SKIPPED, adSkippedEvent);
kalturaPlayer.addEventListener(kalturaPlayer.Event.AD_CLICKED,adClicked);
}
var vlabel = “https://zeenews.india.com”+$(this).attr(“video-path”);
var isVideoPlayed = false;
var isAdSkippedCompleted = false;

function adStartedEvent(event) {
var videotype = “zee english video”;
gtag(‘event’, ‘Adstarted’, { ‘event_category’: videotype, ‘event_label’: vlabel});
gtag(‘event’, ‘Play’, { ‘event_category’: videotype, ‘event_label’: vlabel});
isVideoPlayed = true;
isAdSkippedCompleted = true;
}

function adCompletedEvent(event) {
var videotype = “zee english video”;
gtag(‘event’, ‘Adcompleted’, { ‘event_category’: videotype, ‘event_label’: vlabel});
isAdSkippedCompleted = true;
}

function adSkippedEvent(event) {
var videotype = “zee english video”;
gtag(‘event’, ‘Adskipped’, { ‘event_category’: videotype, ‘event_label’: vlabel});
isAdSkippedCompleted = true;
}

function adClicked(event) {
var videotype = “zee english video”;
gtag(‘event’, ‘Adclicked’, { ‘event_category’: videotype, ‘event_label’: vlabel});
}

function playbackEndedEvent(event){
var videotype = “zee english video”;
gtag(‘event’, ‘Complete’, { ‘event_category’: videotype, ‘event_label’: vlabel});
}

function playEvent(event) {
var videotype = “zee english video”;

if((isVideoPlayed) && (isAdSkippedCompleted)){
isAdSkippedCompleted = false;
}else if((isVideoPlayed)){
gtag(‘event’, ‘resume’, { ‘event_category’: videotype, ‘event_label’: vlabel});
}else{
gtag(‘event’, ‘Play’, { ‘event_category’: videotype, ‘event_label’: vlabel});
isVideoPlayed = true;
}
}

function pauseEvent(event) {
var videotype = “zee english video”;
gtag(‘event’, ‘Pause’, { ‘event_category’: videotype, ‘event_label’: vlabel});
}

function AdloadEvent(event) {
var videotype = “zee english video”;
gtag(“event”, “kaltura_adloaded”, { “event_category”: videotype, “event_label”: vlabel});
}

function AdProgressEvent(event) {
var videotype = “zee english video”;
gtag(“event”, “kaltura_adprogress”, { “event_category”: videotype, “event_label”: vlabel});
}

function adPausedEvent(event) {
var videotype = “zee english video”;
gtag(“event”, “kaltura_adpaused”, { “event_category”: videotype, “event_label”: vlabel});
}
/* End of Kaltura player function code */

$(document).delegate(“div[id^=’play’]”, “click”, function(){
//console.log($(this).attr(“id”));
//console.log($(this).attr(“video-source”));
//console.log($(this).attr(“video-code”));
var isyoutube = $(this).attr(“video-source”);
var vurl = $(this).attr(“video-path”);
var vid = $(this).attr(“id”);
$(this).hide();
var pvid = $(this).attr(“newsid”);
var vx = $(this).attr(“id”).replace(‘play-‘,”);
var vC = $(this).attr(“video-code”);
var playDiv = “video-” + vid + “-” + pvid;
if(isyoutube ==’No’){
kalturaPlayerAPIReady(vC, playDiv,pvid);
}else{
onYouTubePlay(vid, vC, playDiv,vx, pvid);
}
});
$(document).delegate(“div[id^=’ptop’]”, “click”, function(){
var vid = $(this).attr(“id”).replace(‘ptop’,”);
$(this).hide();
var pvid = $(this).attr(“newsid”);
var vurl = $(this).attr(“video-path”);
//console.log($(this).attr(“id”) + “–” + vid);
//console.log($(this).parent().children().find(‘#play-‘+vid).attr(“video-source”));
//console.log($(this).parent().children().find(‘#play-‘+vid).attr(“video-code”));
var isyoutube = $(this).parent().children().find(‘#play-‘+vid).attr(“video-source”);
var vC = $(this).parent().children().find(‘#play-‘+vid).attr(“video-code”);
var playDiv = “mvideo-play-” + vid + “-” + pvid;
if(isyoutube ==’No’){
//console.log(jwplayer($(this).attr(“id”)).getState());
kalturaPlayerAPIReady(vC, playDiv,pvid);

}else{
onYouTubePlay($(this).attr(“id”), vC, playDiv, vid, pvid);
}
});

var nxti = 3;
var ci = 1;
var nxti_1 = 6;
var nxti_2 = 9;
var nxti_3 = 12;
if($.autopager==false){
var use_ajax = false;
/*var disqus_shortname=”zeehindi”;
var disqus_identifier; //made of post id and guid
var disqus_url; //post permalink

function loadDisqus(source, identifier, url, nid) {

if (window.DISQUS) {
//alert(“if”);
jQuery(‘

‘).insertAfter(source);
jQuery(‘#disqus_thread’).insertAfter(source); //append the HTML after the link
//if Disqus exists, call it’s reset method with new parameters
DISQUS.reset({
reload: true,
config: function () {
this.page.identifier = identifier;
this.page.url = url;
}
});
}else{
jQuery(‘

‘).insertAfter(source);
disqus_identifier = identifier; //set the identifier argument
disqus_url = url; //set the permalink argument

//append the Disqus embed script to HTML
var dsq = document.createElement(‘script’); dsq.type=”text/javascript”; dsq.async = true;
dsq.src=”http://” + disqus_shortname + ‘.disqus.com/embed.js’;
jQuery(‘head’).append(dsq);
}
};*/
/*$(‘.disqusOn’).live( “click”, notify );
function notify() {
identifier = $(this).attr(‘id’);
dUrl = $(this).attr(‘disqus-url’);
source = $(this).parent();
loadDisqus(jQuery(this), identifier, dUrl);
}*/
function loadshare(curl){
history.replaceState(” ,”, curl);
if(window.OBR){
window.OBR.extern.researchWidget();
}
//console.log(“loadshare Call->” + curl);
//$(‘html head’).find(‘title’).text(“main” + nxtTitle);
if(_up == false){
var cu_url = curl;
gtag(‘config’, ‘UA-2069755-1’, {‘page_path’: cu_url });

if(window.COMSCORE){
window.COMSCORE.beacon({c1: “2”, c2: “9254297”});
var e = Date.now();
$.ajax({
url: “/marathi/news/zscorecard.json?” + e,
success: function(e) {}
})
}
//console.log(‘ga:’+r);
/*(function () {
var ga = document.createElement(‘script’); ga.type=”text/javascript”; ga.async = true;
ga.src = (‘https:’ == document.location.protocol ? ‘https://’ : ‘http://’) + ‘stats.g.doubleclick.net/dc.js’;
var s = document.getElementsByTagName(‘script’)[0]; s.parentNode.insertBefore(ga, s);
})();*/
//console.log(“loadshare Call”);
}
}
if(use_ajax==false) {
//console.log(‘getting’);
var view_selector=”div.center-section”; // + settings.view_name; + ‘.view-display-id-‘ + settings.display;
var content_selector = view_selector; // + settings.content_selector;
var items_selector = content_selector + ‘ > div.rep-block’; // + settings.items_selector;
var pager_selector=”div.next-story-block > div.view-zn-article-mc-all-2017 > div.view-content > div.clearfix”; // + settings.pager_selector;
var next_selector=”div.next-story-block > div.view-zn-article-mc-all-2017 > div.view-content > div.clearfix > a:last”; // + settings.next_selector;
var auto_selector=”div.tag-block”;
var img_location = view_selector + ‘ > div.rep-block:last’;
var img_path=”

Loading

“; //settings.img_path;
//var img = ‘

‘ + img_path + ‘

‘;
var img = img_path;
//$(pager_selector).hide();
//alert($(next_selector).attr(‘href’));
var x = 0;
var url=””;
var prevLoc = window.location.pathname;
var circle = “”;
var myTimer = “”;
var interval = 30;
var angle = 0;
var Inverval = “”;
var angle_increment = 6;
var handle = $.autopager({
appendTo: content_selector,
content: items_selector,
runscroll: maindiv,
link: next_selector,
autoLoad: false,
page: 0,
start: function(){
$(img_location).after(img);
circle = $(‘.center-section’).find(‘#green-halo’);
myTimer = $(‘.center-section’).find(‘#myTimer’);
angle = 0;
Inverval = setInterval(function (){
$(circle).attr(“stroke-dasharray”, angle + “, 20000”);
//myTimer.innerHTML = parseInt(angle/360*100) + ‘%’;
if (angle >= 360) {
angle = 1;
}
angle += angle_increment;
}.bind(this),interval);
},
load: function(){
$(‘div.loading-block’).remove();
clearInterval(Inverval);
//$(‘.repeat-block > .row > div.main-rhs2337506’).find(‘div.rhs2337506:first’).clone().appendTo(‘.repeat-block >.row > div.main-rhs’ + x);
$(‘div.rep-block > div.main-rhs2337506 > div:first’).clone().appendTo(‘div.rep-block > div.main-rhs’ + x);
$(‘.center-section >.row:last’).before(‘

Next Story

‘);
//$(“.main-rhs” + x).theiaStickySidebar();
var fb_script=document.createElement(‘script’);
fb_script.text= “(function(d, s, id) {var js, fjs = d.getElementsByTagName(s)[0];if (d.getElementById(id)) return;js = d.createElement(s); js.id = id;js.src=”https://connect.facebook.net/en_GB/sdk.js#xfbml=1&version=v2.9″;fjs.parentNode.insertBefore(js, fjs);}(document, ‘script’, ‘facebook-jssdk’));”;
var fmain = $(“.sr”+ x);
//alert(x+ “-” + url);
var fdiv = ‘

‘;
//$(fb_script).appendTo(fmain);
$(fdiv).appendTo(fmain);
FB.XFBML.parse();
var $dfpAd = $(‘.center-section’).children().find(“#ad-“+ x);
xp = “#star”+x;

//var $dfpAdrhs = $(‘.main-rhs’ + x).children().find(‘.adATF’).empty().attr(“id”, “ad-300-” + x); //$(‘.content-area > .main-article > .row > .main-rhs’+x).find(‘#ad-300-‘ + x);
//var $dfpAdrhs2 = $(‘.main-rhs’ + x).children().find(‘.adBTF’).empty().attr(“id”, “ad-300-2-” + x);//$(‘.content-area > .main-article > .row > .main-rhs’+x).find(‘#ad-300-2-‘ + x);
//var $dfpMiddleAd = $(‘.content-area > .main-article > .row’).find(‘#ar’+x).find(‘#ad-middle-‘ + x).empty();
//fillElementWithAd($dfpAdrhs, ‘/11440465/Zeenews_English_Web/Zeenews_English_AS_ATF_300x250’, [[300, 250], [300, 600]], {});
//fillElementWithAd($dfpAdrhs2, ‘/11440465/Zeenews_English_Web/Zeenews_English_AS_BTF_1_300x250’, [300, 250], {});
//fillElementWithAd($dfpMiddleAd, ‘/11440465/Zeenews_Hindi_Article_Middle_300x250_BTF’, [300, 250], {});
var instagram_script=document.createElement(‘script’);
instagram_script.defer=”defer”;
instagram_script.async=”async”;
instagram_script.src=”https://platform.instagram.com/en_US/embeds.js”;

/*var outbrain_script=document.createElement(‘script’);
outbrain_script.type=”text/javascript”;
outbrain_script.async=”async”;
outbrain_script.src=”https://widgets.outbrain.com/outbrain.js”;
var Omain = $(“#outbrain-“+ x);
//alert(Omain + “–” + $(Omain).length);

$(Omain).after(outbrain_script);
var rhs = $(‘.main-article > .row > div.article-right-part > div.rhs2337506:first’).clone();
$(rhs).find(‘.ad-one’).attr(“id”, “ad-300-” + x).empty();
$(rhs).find(‘.ad-two’).attr(“id”, “ad-300-2-” + x).empty();
//$(‘.main-article > .row > div.article-right-part > div.rhs2337506:first’).clone().appendTo(‘.main-article > .row > div.main-rhs’ + x);
$(rhs).appendTo(‘.main-article > .row > div.main-rhs’ + x); */

setTimeout(function(){

var twit = $(“div.field-name-body”).find(‘blockquote[class^=”twitter”]’).length;
var insta = $(“div.field-name-body”).find(‘blockquote[class^=”instagram”]’).length;
if(twit==0){twit = ($(“div.field-name-body”).find(‘twitterwidget[class^=”twitter”]’).length);}
if(twit>0){
if (typeof (twttr) != ‘undefined’) {
twttr.widgets.load();

} else {
$.getScript(‘https://platform.twitter.com/widgets.js’);
}
//$(twit).addClass(‘tfmargin’);
}
if(insta>0){
$(‘.content > .left-block:last’).after(instagram_script);
//$(insta).addClass(‘tfmargin’);
window.instgrm.Embeds.process();
}
}, 1500);
}
});
/*$(“#loadmore”).click(function(){
x=$(next_selector).attr(‘id’);
var url = $(next_selector).attr(‘href’);
disqus_identifier=”ZNH” + x;
disqus_url = url;
handle.autopager(‘load’);
history.pushState(” ,”, url);
setTimeout(function(){
//twttr.widgets.load();
//loadDisqus(jQuery(this), disqus_identifier, disqus_url);
}, 6000);
});*/

/*$(“button[id^=’mf’]”).live(“click”, disqusToggle);
function disqusToggle() {
console.log(“Main id: ” + $(this).attr(‘id’));
}*/
$(document).delegate(“button[id^=’mf’]”, “click”, function(){
fbcontainer=””;
fbid = ‘#’ + $(this).attr(‘id’);
var sr = fbid.replace(“#mf”, “.sr”);

//console.log(“Main id: ” + $(this).attr(‘id’) + “Goodbye!jQuery 1.4.3+” + sr);
$(fbid).parent().children(sr).toggle();
fbcontainer = $(fbid).parent().children(sr).children(“.fb-comments”).attr(“id”);
//console.log(fbcontainer);
//var commentsContainer = document.getElementById(fbcontainer);
//commentsContainer.innerHTML = ”;

});
/************Player Code ***********/
var title, imageUrl, description, author, shortName, identifier, timestamp, summary, newsID, nextnews;
var previousScroll = 0;
//console.log(“prevLoc” + prevLoc);
$(window).scroll(function(){
var last = $(auto_selector).filter(‘:last’);
var lastHeight = last.offset().top ;
//st = $(layout).scrollTop();
//console.log(“st:” + st);
var currentScroll = $(this).scrollTop();
if (currentScroll > previousScroll){
_up = false;
} else {
_up = true;
}
previousScroll = currentScroll;
//console.log(“_up” + _up);

var cutoff = $(window).scrollTop() + 64;
//console.log(cutoff + “**”);
$(‘div[id^=”row”]’).each(function(){
//console.log(“article” + $(this).children().find(‘.left-block’).attr(“id”) + $(this).children().find(‘.left-block’).attr(‘data-url’));
if($(this).offset().top + $(this).height() > cutoff){
//console.log(“$$” + $(this).children().find(‘.left-block’).attr(‘data-url’));
if(prevLoc != $(this).children().find(‘.left-block’).attr(‘data-url’)){
prevLoc = $(this).children().find(‘.left-block’).attr(‘data-url’);
$(‘html head’).find(‘title’).text($(this).children().find(‘.left-block’).attr(‘data-title’));
$(‘meta[name=description]’).attr(“content”,$(this).children().find(‘.left-block’).attr(‘data-summary’));
$(‘meta[name=keywords]’).attr(“content”,$(this).children().find(‘.left-block’).attr(‘data-keyword’));
$(‘meta[name=news_keywords]’).attr(“content”,$(this).children().find(‘.left-block’).attr(‘data-keyword’));

pSUPERFLY.virtualPage(prevLoc,$(this).children().find(‘.left-block’).attr(‘data-title’));
//console.log(“Summary: ” + $(this).children().find(‘.left-block’).attr(‘data-summary’));
//console.log(“Keyword: ” + $(this).children().find(‘.left-block’).attr(‘data-keyword’));
//history.pushState(” ,”, prevLoc);
loadshare(prevLoc);
}
return false; // stops the iteration after the first one on screen
}
});
if(lastHeight + last.height() < $(document).scrollTop() + $(window).height()){
//console.log("**get");
url = $(next_selector).attr('href');
x=$(next_selector).attr('id');
//console.log("x:" + x);
//handle.autopager('load');

/*setTimeout(function(){
//twttr.widgets.load();
//loadDisqus(jQuery(this), disqus_identifier, disqus_url);
}, 6000);*/
}
//lastoff = last.offset();
//console.log("**" + lastoff + "**");
});
//$( ".content-area" ).click(function(event) {
// console.log(event.target.nodeName);
//});

/*$( ".comment-button" ).live("click", disqusToggle);
function disqusToggle() {
var id = $(this).attr("id");
$("#disqus_thread1" + id).toggle();
};*/
//$(".main-rhs2337506").theiaStickySidebar();
var prev_content_height = $(content_selector).height();
//$(function() {
var layout = $(content_selector);
var st = 0;
///});

}
}
});

/*}
};*/
})(jQuery);

(function() {
var reset_scroll;

$(function() {
return $(“[data-sticky_column]”).stick_in_parent({
parent: “[data-sticky_parent]”
});
});

reset_scroll = function() {
var scroller;
scroller = $(“body,html”);
scroller.stop(true);
if ($(window).scrollTop() !== 0) {
scroller.animate({
scrollTop: 0
}, “fast”);
}
return scroller;
};

window.scroll_it = function() {
var max;
max = $(document).height() – $(window).height();
return reset_scroll().animate({
scrollTop: max
}, max * 3).delay(100).animate({
scrollTop: 0
}, max * 3);
};

window.scroll_it_wobble = function() {
var max, third;
max = $(document).height() – $(window).height();
third = Math.floor(max / 3);
return reset_scroll().animate({
scrollTop: third * 2
}, max * 3).delay(100).animate({
scrollTop: third
}, max * 3).delay(100).animate({
scrollTop: max
}, max * 3).delay(100).animate({
scrollTop: 0
}, max * 3);
};

$(window).on(“resize”, (function(_this) {
return function(e) {
return $(document.body).trigger(“sticky_kit:recalc”);
};
})(this));

}).call(this);

body{overflow:hidden}
.article-tag-link{margin:5px 0px;padding:0px;font-size:14px;font-weight:700;color:#e21727;text-transform:uppercase;}
.article-tag-link a{color:#e21727;}
.article-widgetpara{font-size:38px;color:#191c20;line-height:normal;margin-bottom:10px;}
.article-widgetpara a{font-size:38px;color:#191c20;line-height:normal;}
.widget-image-block{position:relative;height:270px;overflow:hidden;}
.stry_ldmore{width:100%;position:absolute;bottom:0px;text-align:center;display:block;}
.stry_fdr{bottom:0;background:linear-gradient(to bottom, rgba(255, 255, 255, 0) 0%, rgba(255, 255, 255, 1) 100%) repeat scroll 0 0 rgba(0, 0, 0, 0);height:200px;position:absolute;width:100%;}
.stry_shwmre{background:#2089ff;color:#FFF;cursor:pointer;padding:10px 20px;text-align:center;position:relative;display:inline-block;left:50%;margin-left:-83px;border-top-left-radius:5px;border-top-right-radius: 5px;}
.stry_shwmre:hover{background:#1581f9}
.wid-line{border-bottom:1px solid #2089ff; position:absolute;bottom:0;width:100%;}
.widget-vs{padding-left:inherit;padding-right:inherit;}
.white-txt{color:#FFF !important;}
.article-head-block p{font-size:18px;color:#444;line-height:26px}
.play-b{width:70px;height:70px;top:50%;left:50%;position:absolute;z-index:1009;cursor:pointer;margin-left:-35px;margin-top:-35px;bottom:inherit;right:inherit;}

.kaltura-player-container{position: relative; top: 0px; right: 0; bottom: 0; left: 0; width: 100%; height: 500px;}
.playkit-player-gui{display:block !important;}

function on_load_google_ad(){
var inad1, inad2 = ”;
googletag.cmd.push(function() {
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_ATF_970x90’, [[970, 90], [970, 250], [970, 66], [728, 90]], ‘div-gpt-ad-1504525832454-0’).addService(googletag.pubads().setTargeting(‘category’, [“Health”,”Head And Neck Cancer”,”Cancer Therapy”,”University Of Cincinnati”]));
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_ATF_300x250’, [[300, 600], [300, 250]], ‘div-article-rhs-atf-ad’).addService(googletag.pubads().setTargeting(‘category’, [“Health”,”Head And Neck Cancer”,”Cancer Therapy”,”University Of Cincinnati”]));
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_BTF_1_300x250’, [300, 250], ‘div-gpt-ad-1504525832454-2’).addService(googletag.pubads().setTargeting(‘category’, [“Health”,”Head And Neck Cancer”,”Cancer Therapy”,”University Of Cincinnati”]));
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_OOP_1x1’, [1, 1], ‘div-gpt-ad-1504526235866-6’).addService(googletag.pubads().setTargeting(‘category’, [“Health”,”Head And Neck Cancer”,”Cancer Therapy”,”University Of Cincinnati”]));
var inarticle1 = document.getElementById(‘div-gpt-ad-AS-Inarticle-1’);
if (typeof(inarticle1) != ‘undefined’ && inarticle1 != null)
{
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_Inarticle_1_300x250’, [[300, 250]], ‘div-gpt-ad-AS-Inarticle-1’).addService(googletag.pubads().setTargeting(“category”, [“Health”,”Head And Neck Cancer”,”Cancer Therapy”,”University Of Cincinnati”]));
inad1 = “true”;
}
var inarticle2 = document.getElementById(‘div-gpt-ad-AS-Inarticle-2’);
if (typeof(inarticle2) != ‘undefined’ && inarticle2 != null)
{
googletag.defineSlot(‘/11440465/Zeenews_English_Web/Zeenews_English_AS_Inarticle_2_300x250’, [[300, 250]], ‘div-gpt-ad-AS-Inarticle-2’).addService(googletag.pubads().setTargeting(“category”, [“Health”,”Head And Neck Cancer”,”Cancer Therapy”,”University Of Cincinnati”]));
inad2 = “true”;
}
googletag.pubads().disableInitialLoad();
googletag.pubads().enableAsyncRendering();
googletag.pubads().set(‘page_url’,’https://zeenews.india.com/’);
googletag.pubads().enableSingleRequest();
googletag.pubads().collapseEmptyDivs();
googletag.enableServices();
});
googletag.cmd.push(function() { googletag.display(‘div-article-rhs-atf-ad’); });
googletag.cmd.push(function() { googletag.display(‘div-gpt-ad-1504525832454-0’); });
googletag.cmd.push(function() { googletag.display(‘div-gpt-ad-1504525832454-2’); });
googletag.cmd.push(function() { googletag.display(‘div-gpt-ad-1504526235866-6’); });

}
on_load_google_ad();
function sendAdserverRequest() {
try {
if (pbjs && pbjs.adserverRequestSent) return;
googletag.cmd.push(function() {
googletag.pubads().refresh();
});
} catch (e) {

googletag.cmd.push(function() {
googletag.pubads().refresh();
});
}
}
setTimeout(function() { sendAdserverRequest(); }, 5000);

function on_load_fb_twitter_widgets(){
(function(d, s, id) {
var js, fjs = d.getElementsByTagName(s)[0];
if (d.getElementById(id)) return;
js = d.createElement(s); js.id = id;
js.src = “https://connect.facebook.net/en_US/sdk.js#xfbml=1&version=v2.9”;
fjs.parentNode.insertBefore(js, fjs);
}(document, ‘script’, ‘facebook-jssdk’));

window.twttr = (function(d, s, id) {
var js, fjs = d.getElementsByTagName(s)[0],
t = window.twttr || {};
if (d.getElementById(id)) return t;
js = d.createElement(s);
js.id = id;
js.src = “https://platform.twitter.com/widgets.js”;
fjs.parentNode.insertBefore(js, fjs);
t._e = [];
t.ready = function(f) {

t._e.push(f);
};
return t;
}(document, “script”, “twitter-wjs”));
}

//setTimeout(function() { on_load_google_ad(); }, 5000);
setTimeout(function() {
on_load_fb_twitter_widgets();
}, 5000);



Source link

Most Popular

Recent Comments